STAT4: An Initiator of Meta-Inflammation in Adipose Tissue?
نویسندگان
چکیده
منابع مشابه
STAT4: An Initiator of Meta-Inflammation in Adipose Tissue?
Metabolic regulation and immune signaling are closely linked, as evidenced by both the physical proximity between metabolic cells (e.g., adipocytes and hepatocytes) and resident macrophages as well as the progression of inflammation in metabolic syndrome. Contrasting the reactions to pathogen infections, meta-inflammation describes a novel type of lowgrade, unresolvable immune response that is ...
متن کاملKey Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation
Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obese mice. The objective of this study was to determine the contribution of selective STAT4 deficiency in subsets of hematopoietic cells to IR and AT ...
متن کاملSTAT4 Deficiency Reduces Obesity-Induced Insulin Resistance and Adipose Tissue Inflammation
Signal transducer and activator of transcription (STAT) 4 is one of the seven members of the STAT family. STAT4 has a prominent role in mediating interleukin-12-induced T-helper cell type 1 lineage differentiation. T cells are key players in the maintenance of adipose tissue (AT) inflammation. The role of STAT4 in obesity and AT inflammation is unknown. We sought to determine the role of STAT4 ...
متن کاملRole of Adipose Tissue in Metabolic System Disorders Adipose Tissue is the Initiator of Metabolic Diseases
Fats are one of the most important components of the human body, which are distributed as structural and metabolic molecules. Lipids are sporadically present in different tissues, i.e. bone marrow, brain and AT. AT is one of the largest and highly specialized connective tissues, and that is composed of different cell types. This diversity of cells in the AT represents its vast function and impo...
متن کاملinflammation in metabolic syndrome: role of adipose tissue
metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as c-reactive protein (crp), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. higher...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2013
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db13-1416